Publication list

Selected publications

[23] Colman MA "Arrhythmia Mechanisms and Spontaneous Calcium Release: Bi-directional Coupling Between Re-entrant and Focal Excitation" PLOS Comput Biol. 2019 Aug 8;15(8):e107260.

[22] Kettlewell S, Saxena P, Dempster J, Colman MA, Mycles RC, Smith GL and Workman AJ "Dynamic clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarizations ". Journal of Physiol., May 2019.

[21] Perez Alday EA, Whittaker DG, Benson AP and Colman MA "Effects of Heart Rate and Ventricular Wall Thickness on Non-invasive Mapping: An in silico Study". Front. Physiol., 05 April 2019.

[20] Sheard TMB, Hurley ME, Colyer J .. Colman MA and Jayasinghe I. "Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy" ACS Nano 2019, 13 (2), pp 2143–2157.

[17] Colman MA, Saxena P, Kettlewell S, Workman AJ. "Description of the human atrial action potential derived from a single, congruent data source: Novel computational models for integrated experimental-numerical study of atrial arrhythmia mechanisms" Front. Physiol 2018.

[16] Colman MA , Perez Alday EA, Holden AV, Benson AP "Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator" Front. Physiol. 2017

[15] Colman MA , Pinali C, Trafford AW, Zhang H, Kitmitto A. "A Computational Model of Spatio-Temporal Cardiac Intracellular Calcium Handling with Realistic Structure and Spatial Flux Distribution from Sarcoplasmic Reticulum and T-tubules Reconstructions" PLOS Comp. Bio. 13(8).e1005714, 2017

[13] Perez Alday EA, Colman MA , Langley P, Zhang H. "Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs: A computational study" PLOS Comp. Bio. 2017

[5] Colman MA, Aslanidi OV, Kharche S, Boyett MR, Garratt CJ, Hancox JC and Zhang H. "Pro-arrhythmogenic Effects of Atrial Fibrillation Induced Electrical Remodelling - Insights from 3D Virtual Human Atria." J Physiol, 2013, 591, 4249-4272.

Journal Articles

Books and book chapters

    Colman MA, Holden AV. Chapter: “Modeling the heart” in “Encyclopaedia of Biophysics”, Springer 2019.

    Colman MA “Mechanisms of atrial arrhythmias - Insights from the development of a biophysically detailed model of the human atria.” Springer Theses Series, ISBN 978-3-319-01643-6, 2014.

Peer reviewed conference papers

    Holmes M, Benson AP, Aslanidi OV, Colman MA. “Investigating Calcium-Mediated Arrhythmias via a Computational Model of a Rabbit Atrial Myocyte”. Computing in Cardiology (CinC), 2018.

    Whittaker DG, Benson AP, Teh I, Schneider JE, Colman MA, “Role of cardiac Microstructure Variability on Ventricular Arrhythmogenesis” Computing in Cardiology (CinC), 2018

    Stevenson-Cocks HJ, Colman MA, Benon AP, White E. “Inward rectifier current downregulation promotes spontaneous calcium release in a novel model of rat ventricular electrophysiology” Computing in Cardiology (CinC), 2018

    Jones G, Zhang H, Colman MA. “The Effect of Bioenergetic Impairment of Cytosolic Process in Spatio-Temporal Ca2+ dynamics in a Three-Dimensional Cardiomyocyte Model”. In Computing in Cardiology (CinC), 2016

    Colman MA, Macquaide N, Workman A. “A New Model of the Human Atrial Myocyte with Variable T-tubule Organisation for the Study of Atrial Fibrillation”. In Computing in Cardiology (CinC), 2016

    Perez Alday EA, Colman MA, Zhang H. “Reconstruction of Atrial Ectopic Focal and Re-entrant Excitation from body Surface Potentials: Insights from 3D Virtual Human Atria and Torso” In Computing in Cardiology (CinC), 2016.

    Benson A, Colman MA, Holden A, Kagugube G, Pervolarki E. “Computational Modelling of Cardiac Electrophysiological Changes in Acute Malaria”. In Computing in Cardiology (CinC), 2016

    Colman MA, Parra-Rojas C, Perez Alday EA. “From Microscopic Calcium Sparks to the ECG: Model Reduction Approaches for Multi-Scale Cardiac Simulation” In Computing in Cardiology (CinC), 2015.

    Jones GM, Colman MA, Zhang H. “Quantification of the Effects of Electrical Remodelling due to Hypertrophic Cardiomyopathy on Human Ventricular Electromechanical Activity and Energetics” In Computing in Cardiology (CinC), 2015.

    Perez Alday EA, Zhang C, Colman MA, Ni H, Gan Z, Zhang H. “Comparison of Electric and Magnetic Cardiograms Produced by Myocardial Ischemia in Models of the Human Ventricle and Torso” In Computing in Cardiology (CinC), 2015.

    Whittaker DG, Colman MA, Hancox JC, Zhang H. “In silico Investigation of Short QT Syndrome-Linked Potassium Channel Mutations on Electro-Mechanical Function of Human Atrial Cells” In Computing in Cardiology (CinC), 2015.

    Kottas P, Colman MA, Stephenson RS, Castro SJ, Jarvis JC, Boyett MR, Zhang H. “Effect of Cardiac Structural Remodelling During Heart Failure on Cardiac Excitation” In Computing in Cardiology (CinC), 2015 (In Press).

    Colman MA, Kharche SR, Zhang H. “Loss of Transverse-Tubules Promotes the Development of Ectopic Activity in Guinea-pig Ventricle” In Computing in Cardiology (CinC), 2014, pp 1129-1132

    Ni H*, Colman MA*, Zhang H. “Modelling the Functional Impact of KCNA5 Mutations on the Electrical and Mechanical Activities of Human Atrial cells” In Computing in Cardiology (CinC), 2014, pp 57-60

    Kharche S, Castro S, Thomas B, Colman MA, Jarvis J, Smaill B, Zhang H. “Role of Fiber Orientation in Atrial Arrhythmogenesis” In Computing in Cardiology (CinC), 2014

    Perez Alday EA*, Colman MA*, Langley P, Zhang H. “Spatial Refinement of a New Algorithm to Identify Focus of Atrial Ectopic Activity from 64-lead ECGs” In Computing in Cardiology (CinC), 2014, pp 501-504

    Perez Alday EA*, Colman MA*, Butters TD, Higham J, Giacopelli D, Langley P & Zhang H. “Diagnosis of atrial ectopic origin from body surface ECG – insights from 3D virtual human atria and torso.” In Computing in Cardiology (CinC), 2013, pp 1075-1078

    Castro SJ, Colman MA, Kharche S, Wang R & Zhang H. “HCN and SCN5A channel mutations: implications for impaired atrioventricular nodal conduction in a heterogeneous computer model of the whole mouse heart.” In Computing in Cardiology (CinC), 2013, pp 41-44.

    Aslanidi OV*, Colman MA*, Zhao J, Smaill BH, Gilbert SH, Hancox JC, Boyett MR & Zhang H. “Arrhythmogenic substrate for atrial fibrillation: Insights from an integrative computational model of pulmonary veins.” In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2012, pp. 203 –206.

    Colman MA, Giacopelli D, Langley P & Zhang H. “Elucidating the body surface P-wave using a detailed computer model of atrial activation.” In Computing in Cardiology (CinC), 2012, pp. 129–132.

Abstracts

    Colman MA, “Multi-scale coupling between sub-cellular release events and re-entrant excitation in the heart”, NCRG, 2019.

    Whittaker DG, Benson AP, Teh I, Schneider JE, Colman MA, “Computational assessment of the Role of cardiac Microstructure Variability in Ventricular arrhythmia dynamics” Europhysiology, 2018

    Stevenson-Cocks HJ, Colman MA, Benon AP, White E. “Inward rectifier current downregulation promotes spontaneous calcium release in a novel model of rat ventricular electrophysiology” Europhysiology, 2018.

    Colman MA, “Multi-scale coupling between sub-cellular release events and re-entrant excitation in the heart”, Europhysiology, 2018.

    Holmes M, Benson AP, Aslanidi OV, Colman MA. “Detubulation promotes Ca2+ transient alternans in a model of the rabbit atrial myocyte”. Europhysiology, 2018.

    Colman MA, “Dynamic Organ-Scale Modelling of Sub-Cellular Calcium Release Events in the Heart: After-Depolarisations, Premature Excitation and Re-entry”, Heart By Numbers, 2018.

    Holmes M, Benson AP, Aslanidi OV, Colman MA. “Investigating Calcium-Mediated Arrhythmias via a Computational Model of a Rabbit Atrial Myocyte”. Heart By Numbers, 2018.

    Whittaker DG, Benson AP, Teh I, Schneider JE, Colman MA, “Role of cardiac Microstructure Variability on Ventricular Arrhythmogenesis” Computing in Cardiology (CinC), 2018

    Holmes M, Benson AP, Aslanidi OV, Colman MA. “A Novel Model of Rabbit Atrial Cardiomyocytes for the Study of Spontaneous Ca2+ Release Mediated Arrhythmic Mechanisms”. Computing in Cardiology (CinC), 2018.

    Colman MA, Perez Alday EA, Holden AV, Benson AP, “Trigger versus Substrate: Multi-Scale Considerations for Arrhythmia Modulation by Pharmacological Action” Biophysical Journal 2018.

    Stevenson-Cocks HJ, Colman MA, Benon AP, White E. “Inward rectifier current downregulation promotes spontaneous calcium release in a novel model of rat ventricular electrophysiology” Computing in Cardiology (CinC), 2018

    Colman MA, “Multi-scale Simulation of Spontaneous Calcium Release Events in the Human Atria”. In EMBEC’17 & NBC’17, 2017.

    Stevenson-Cocks H, Colman MA, White E, Benson AP. “Mechanisms of arrhythmia triggers in heart failure predicted by a novel model of rat ventricular electrophysiology” Future Physiology 2017

    Colman MA, “Multi-scale Simulation of Spontaneous Calcium Release Events in the Human Atria”, ICE 2017.

    Colman MA, Macquaide N, Workman A. “A New Model of the Human Atrial Myocyte with Variable T-tubule Organisation for the Study of Atrial Fibrillation”. In Virtual Physiological Human conference (VPH), 2016

    Jones G, Zhang H, Colman MA. “The Effect of Bioenergetic Impairment of Cytosolic Process in Spatio-Temporal Ca2+ dynamics in a Three-Dimensional Cardiomyocyte Model”. In Computing in Cardiology (CinC), 2016

    Colman MA, Macquaide N, Workman A. “A New Model of the Human Atrial Myocyte with Variable T-tubule Organisation for the Study of Atrial Fibrillation”. In Computing in Cardiology (CinC), 2016

    Perez Alday EA, Colman MA, Zhang H. “Reconstruction of Atrial Ectopic Focal and Re-entrant Excitation from body Surface Potentials: Insights from 3D Virtual Human Atria and Torso” In Computing in Cardiology (CinC), 2016.

    Workman AJ, Kettlewell S, Dempster J, Colman MA, Rannkin AC, Myles RC, Smith GL. “A Dynamic Clamp Study of L-type Ca2+ Current in Rabbit and Human Atrial Myocytes: The Contribution of Window ICaLto Early Afterdepolarisations”. Heart Rhythm Congress 2016.

    Benson A, Colman MA, Holden A, Kagugube G, Pervolarki E. “Computational Modelling of Cardiac Electrophysiological Changes in Acute Malaria”. In Computing in Cardiology (CinC), 2016

    Colman MA, Parra-Rojas C, Perez Alday EA. “From Microscopic Calcium Sparks to the ECG: Model Reduction Approaches for Multi-Scale Cardiac Simulation” In Computing in Cardiology (CinC), 2015.

    Jones GM, Colman MA, Zhang H. “Quantification of the Effects of Electrical Remodelling due to Hypertrophic Cardiomyopathy on Human Ventricular Electromechanical Activity and Energetics” In Computing in Cardiology (CinC), 2015.

    Perez Alday EA, Zhang C, Colman MA, Ni H, Gan Z, Zhang H. “Comparison of Electric and Magnetic Cardiograms Produced by Myocardial Ischemia in Models of the Human Ventricle and Torso” In Computing in Cardiology (CinC), 2015.

    Whittaker DG, Colman MA, Hancox JC, Zhang H. “In silico Investigation of Short QT Syndrome-Linked Potassium Channel Mutations on Electro-Mechanical Function of Human Atrial Cells” In Computing in Cardiology (CinC), 2015.

    Kottas P, Colman MA, Stephenson RS, Castro SJ, Jarvis JC, Boyett MR, Zhang H. “Effect of Cardiac Structural Remodelling During Heart Failure on Cardiac Excitation” In Computing in Cardiology (CinC), 2015.

    Whittaker DG, Colman MA, Hancox JC, Zhang H. “In silico study of the effects of hERG-linked short QT syndrome on the electrical and mechanical activities of human atrial cells”. The Physiological Society Meeting, 2015.

    Ni H, Colman MA, Zhang H (2014) “Modelling the Functional Impact of KCNA5 Mutations on the Electrical and Mechanical Activities of Human Atrial cells.” Virtual Physiological Human Network of Excellence (VPH)

    Colman MA, Kharche SR, Zhang H (2014). “Loss of Transverse-Tubules Promotes the Development of Ectopic Activity in Guinea-pig Ventricle” In Computing in Cardiology (CinC)

    Ni H, Colman MA, Zhang H (2014). “Modelling the Functional Impact of KCNA5 Mutations on the Electrical and Mechanical Activities of Human Atrial cells” Computing in Cardiology (CinC)

    Kharche S, Castro S, Thomas B, Colman MA, Jarvis J, Smaill B, Zhang H (2014). “Role of Fiber Orientation in Atrial Arrhythmogenesis” Computing in Cardiology (CinC)

    Perez Alday EA*, Colman MA*, Langley P, Zhang H (2014). “Spatial Refinement of a New Algorithm to Identify Focus of Atrial Ectopic Activity from 64-lead ECGs” Computing in Cardiology (CinC)

    Colman MA, Asalnidi OV & Zhang H (2013). “The role of the Pulmonary veins in the development of atrial fibrillation.” European Muscle Conference (EMC)

    Colman MA, Ni H & Zhang H (2013). “Pro-arrhythmic effects of IKur mutations in the human atria.” European Muscle Conference (EMC)

    Colman MA, Castro SJ & Zhang H (2013). “Mechanisms of atrio-ventricular nodal block.” European Muscle Conference (EMC)

    Colman MA, Aslanidi OV, Kharche SR, Boyett MR & Zhang H (2013). “The effect of AF-induced electrical remodelling on regional electrical heterogeneity and tissue vulnerability to atrial fibrillation—insights from modelling.” Journal of Electrocardiology 46 (4) e18-e18

    Varela M, Colman MA, Zhang H & Aslanidi OV (2013). “Realistic heterogeneous and anisotropic canine atrial model for the study of atrial arrhythmias.” Journal of Electrocardiology 46 (4) e10-e11

    Perez Alday EA, Colman MA, Langley P, Holden AV & Zhang H (2013). “Multi-scale integrative model of the human atria and torso: a platform for the investigation of atrial arrhythmias.” Journal of Electrocardiology 46 (4) e17-e18

    Perez Alday EA, Colman MA, Butters TD, Higham J, Giacopelli D, Langley P & Zhang H (2013). “Diagnosis of atrial ectopic origin from body surface ECG – insights from 3D virtual human atria and torso.” Computing in Cardiology (CinC)

    Castro SJ, Colman MA, Kharche S, Wang R & Zhang H (2013). “HCN and SCN5A channel mutations: implications for impaired atrioventricular nodal conduction in a heterogeneous computer model of the whole mouse heart.” Computing in Cardiology (CinC)

    Colman MA, Aslanidi OV & Zhang H (2012). “Multi-scale integrative computational model of the human atria and torso: a platform for the investigation of atrial fibrillation.” Virtual Physiological Human Network of Excellence (VPH)

    Colman MA, Varela M & Aslanidi OV (2012). “Multi-scale integrative computational model of pulmonary veins: studying arrhythmogenic substrate for atrial fibrillation.” Virtual Physiological Human Network of Excellence (VPH)

    Colman MA, Boyett MR & Zhang H (2012). “Autonomic regulation in the virtual 3D human atria.” Cardiac and Respiratory themed meeting of the physiological society

    Zhang H, Colman MA, Garratt C, Dobrzynski H & Boyett MR (2012). “Multi-physical computer model of the human atria and torso: a platform for the study of atrial fibrillation.” Cardiac and Respiratory themed meeting of the physiological society

    Colman MA, Giacopelli D, Langley P & Zhang H (2012). “Elucidating the body surface P-wave using a detailed computer model of atrial activation”. Computing in Cardiology (CinC)

    Colman MA, Rabinovich A, Saraee S & Zhang H (2012). “Properties of four human atrial cell models: Action potential, memory and ion channel kinetics in single cells.” Computing in Cardiology (CinC)

    Colman MA, Stott J, Boyett MR & Zhang H (2010). “Simulation of Inverted P-waves due to Pacemaking Site Shifts in Healthy Subjects.” Virtual Physiological Human Network of Excellence (VPH)